Dr. rer. nat. Daniel Wesner
Phone: +49 (0)271 740 3841
In the human body cells grow in a 3-dimensional environment with direct contact to neighbouring cells and the extracellular matrix (ECM). This matrix is a scaffold that provides mechanical and chemical signals that are indispensable for differentiation and normal growth of the cells. To analyze these interactions and improve existing 2D techniques of cell culture we develop suitable model systems that provide asymmetric 3D microenvironments resembling the situation in vivo. We design polymeric surfaces and scaffolds of a variety of different properties that are characterized by physical techniques on the micro and nanoscale. The reactions of the cells grown in these structures are examined by different microscopical and biochemical methods. To analyze the topography and mechanical properties especially of soft matter several atomic force microscopes (AFM) are available in the group.