Mitarbeiter
Prof. Dr. Sybille Krauss (Leitung) | ||
| Raum | AR-C 3009 | |
| Telefon | 0049-(0)271/740-2273 | |
| Fax | 0049-(0)271/740-12273 | |
| Sprechstunde | nach Vereinbarung | |
| Anschrift | Institut für Biologie Naturwissenschaftlich-Technische Fakultät Universität Siegen Adolf-Reichwein-Str. 2 57068 Siegen | |
| Sekretariat | ||
Publikationen
Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease. Judith Schilling, Meike Broemer, Ilian Atanassov, Yvonne Duernberger, Ina Vorberg, Christoph Dieterich, Alina Dagane, Gunnar Dittmar, Erich Wanker, Willeke van Roon-Mom, Jennifer Winter, Sybille Krauß. Journal of Molecular Biology (2019) doi.org/10.1016/j.jmb.2019.01.034
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer’s disease model. Nicole Reichenbach, Andrea Delekate, Monika Plescher, Franziska Schmitt, Sybille Krauss, Nelli Blank, Annett Halle & Gabor C Petzold. EMBO Molecular Medicine (2019) DOI 10.15252/emmm.201809665
Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease Arnoux, M. Isabelle Arnoux, Michael Willam, Nadine Griesche, Jennifer Krummeich, Hirofumi Watari, Nina Offermann, Stephanie Weber, Partha Narayan Dey, Changwei Chen, Olivia Monteiro, Sven Buettner, Katharina Meyer, Daniele Bano, Konstantin Radyushkin, Rosamund Langston, Jeremy J Lambert, Erich Wanker, Axel Methner, Sybille Krauss*, Susann Schweiger*, Albrecht Stroh*, * corresponding authors eLIFE (2018) doi: 10.7554/eLife.38744
Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients. Sybille Krauß, Rohit Nalavade, Stephanie Weber, Katlynn Carter,Bernd Evert MicroRNA (2018) DOI : 10.2174/2211536607666180821162403
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. Bernd O. Evert, Rohit Nalavade, Johannes Jungverdorben, Stephanie Weber, Ashish Rajput, Stefan Bonn, Oliver Brüstle, Michael Peitz, Sybille Krauß PLOS ONE (2018) doi.org/10.1371/journal.pone.0201794
Reducing mutant Huntingtin protein expression in living cells by a newly identified RNA CAG binder. Frank Matthes, Serena Massari, Anna Bochicchio, Kenji Schorpp, Judith Schilling, Stephanie Weber, Nina Offermann, Jenny Desantis, Erich Wanker, Paolo Carloni, Kamyar Hadian, Oriana Tabarrini, Giulia Rossetti, Sybille Krauss. ACS Chem Neurosci. (2018), doi: 10.1021/acschemneuro.8b00027
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures. Olivia Monteiro, Changwei Chen, Ryan Bingham, Argyrides Argyrou, Rachel Buxton, Christina Pancevac Jönsson, Emma Jones, Angela Bridges, Kelly Gatfield, Sybille Krauß, Jeremy Lambert, Rosamund Langston, Susann Schweiger and Iain Uings. Neuroscience Letters (2018) https://doi.org/10.1016/j.neulet.2018.02.061
Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Frank Matthes, Moritz M. Hettich, Judith Schilling, Diana Flores-Dominguez, Nelli Blank, Thomas Wiglenda, Alexander Buntru, Hanna Wolf, Stephanie Weber, Ina Vorberg, Alina Dagane, Gunnar Dittmar, Erich Wanker, Dan Ehninger, Sybille Krauss. Cell Death Discovery. (2018) 4:4, DOI 10.1038/s41420-017-0003-8
MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression. Kristoffer Unterbruner, Frank Matthes, Judith Schilling, Rohit Nalavade, Stephanie Weber, Jennifer Winter, Sybille Krauß. PLOS ONE (2018) https://doi.org/10.1371/journal.pone.0190437
The role of microRNAs in spinocerebellar ataxia type 3. Sybille Krauss and Bernd Oliver Evert. Journal of Molecular Biology. (2019) doi.org/10.1016/j.jmb.2019.01.019 Impact Factor (2017): 4.894
tFRAP: A FRAP-Based Technique to Monitor Protein Translation in Living Cells. Nadine Griesche, Verena Pesch, Rohit Nalavade, Stephanie Weber, Ireen König, Manuel Schölling, Christoph Möhl and Sybille Krauß. J Anal Bioanal Tech. (2017) DOI: 10.4172/2155-9872.1000390.
Mechanisms of RNA-Induced Toxicity in Diseases Characterised by CAG Repeat Expansions. Judith Schilling, Nadine Griesche, Sybille Krauß. eLS. John Wiley & Sons, Ltd: Chichester (2016) DOI:10.1002/9780470015902.a0026464 Impact factor not available
The MID1 protein is a central player during development and in disease. Jennifer Winter, M. Felicia Basilicata, Marc P. Stemmler, Sybille Krauss. Front Biosci (Landmark Ed) (2016); 21:664-82
A validated antibody panel for the characterization of tau post-translational modifications. Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer. Molecular Neurodegeneration. (2017) doi.org/10.1186/s13024-017-0229-1.
Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Susann Schweiger, Frank Matthes, Karen Posey, Eva Kickstein, Stephanie Weber, Moritz M. Hettich, Sandra Pfurtscheller, Dan Ehninger, Rainer Schneider, Sybille Krauß. Scientific Reports. (2017) doi:10.1038/s41598-017-12974-4.
Regulation of mRNA translation by MID1: a common mechanism of expanded CAG repeat RNAs. Nadine Griesche, Judith Schilling, Stephanie Weber, Marlena Rohm, Verena Pesch, Frank Matthes, Georg Auburger and Sybille Krauss. Front. Cell. Neurosci. 2016; doi: 10.3389/fncel.2016.00226.
Molecular View of Ligands Specificity for CAG Repeats in Anti-Huntington Therapy. Anna Bochicchio, Giulia Rossetti, Oriana Tabarrini, Sybille Krauß, and Paolo Carloni. J. Chem. Theory Comput. 2015; DOI: 10.1021/acs.jctc.5b00208.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Jens Wagner, Sybille Krauss, Song Shi, Sergey Ryazanov, Julia Steffen, Carolin Miklitz, Andrei Leonov, Alexander Kleinknecht, Bettina Göricke, Jochen H. Weishaupt, Daniel Weckbecker, Anne M. Reiner, Wolfgang Zinth, Johannes Levin, Dan Ehninger, Stefan Remy, Hans A. Kretzschmar, Christian Griesinger, Armin Giese, Martin Fuhrmann. Acta Neuropathol (2015) 130:619–631. DOI 10.1007/s00401-015-1483-3.
The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. Susann Schweiger, Stephanie Dorn, Melanie Fuchs, Andrea Köhler, Eva-Christina Müller, Erich Wanker, Rainer Schneider, Sybille Krauß. JBC, 2014; DOI: 10.1074/jbc.M113.541219.
The anti-diabetic drug metformin reduces BACE1 protein levels by interfering with the MID1 complex. Moritz M. Hettich, Frank Matthes, Devon P. Ryan, Nadine Griesche, Susanne Schröder, Stephanie Dorn, Sybille Krauss, Dan Ehninger PLoS ONE, 01/2014; 9(7):e102420. DOI: 10.1371/journal.pone.0102420.
A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signalling. Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I. Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker, Rainer Schneider. Mol Cancer. 2014 Jun 9;13(1):146.
Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. BI Pérez-Revuelta, MM Hettich, A Ciociaro, C Rotermund, PJ Kahle, S Krauss and DA Di Monte. Cell Death Dis. 2014 May 8;5:e1209. doi: 10.1038/cddis.2014.175.
Mechanisms of RNA-induced toxicity in CAG repeat disorders. R Nalavade, N Griesche, DP Ryan, S Hildebrand and S Krauß. Cell Death and Disease (2013) 4, e752; doi:10.1038/cddis.2013.276
Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins. Sybille Krauss and Ina Vorberg. International Journal of Cell Biology Volume 2013, Article ID 704546, dx.doi.org/10.1155/2013/704546 
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex. Sybille Krauß, Nadine Griesche, Ewa Jastrzebska, Changwei Chen, Désiree Rutschow, Clemens Achmüller, Stephanie Dorn, Sylvia M. Boesch, Maciej Lalowski, Erich Wanker, Rainer Schneider, Susann Schweiger. Nat Commun. 2013;4:1511. doi: 10.1038/ncomms2514.
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3. Araujo J, Breuer P, Dieringer S, Krauss S, Dorn S, Zimmermann K, Pfeifer A, Klockgether T, Wuellner U, Evert BO. Hum Mol Genet. 2011 Aug 1;20(15), 2928-41.
Control of mTORC1 signaling by the Opitz syndrome protein MID1. Enbo Liu, Christine A. Knutzen, Sybille Krauss, Susann Schweiger, and Gary G. Chiang. Proc Natl Acad Sci U S A. 2011 May 24;108(21): 8680-5.
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signalling. Eva Kickstein*, Sybille Krauss*, Paul Thornhill, Desirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Hartmut Glossmann, Rainer Schneider, Calum Sutherland & Susann Schweiger. *shared first authors. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5.